wood carved in shape of a brain filled with green happy emojis and medications Key Takeaway: Zoloft (sertraline) is generally the first-line choice for anxiety, depression, and OCD. Wellbutrin (bupropion) is often preferred when patients want to avoid weight gain or sexual side effects, or when they also struggle with low energy, brain fog, or ADHD. The right choice depends on your full symptom picture — which is exactly what a psychiatric evaluation is designed to uncover.
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